Severe sepsis is the leading reason for ICU admission. By definition severe sepsis leads to various organ system failures potentially placing these category of critically ill patients at high risk of death. Sepsis is the most common pathway to death after an infection. Worldwide every three seconds someone dies from sepsis.
To provide healthcare providers with the latest scientific information the Surviving Sepsis Campaign was launched 15 years ago to improve outcome of patients with severe sepsis. Evidencebased guidelines were developed to optimize care of patients with severe sepsis and septic shock and reduce mortality. Bundle programs based on the guidelines over the last decade have shown to reduce mortality, although underlying scientific evidence has been heavily debated.
Probably the most importing aspect of sepsis is the early recognition of signs and symptoms. An early diagnosis and prompt institution of adequate therapeutic interventions such as antibiotics is of paramount importance.